On the Inheritance of Microbiome-Deficiency: Paediatric Functional Gastrointestinal Disorders, the Immune System and the Gut–Brain Axis

Like the majority of non-communicable diseases that have recently gained attention, functional gastrointestinal (GI) disorders (FGID) in both children and adults are caused by a variety medical conditions. In general, while it is often thought common conditions such as obesity may cause other problems, for example, asthma or mental health issues, more consideration needs to be given possibility they could brought on single underlying problem. Based variations disease, recent years, our group has been revisiting exact role intestinal microbiome within Vertebrata. While metabolic products play adult, tentative conclusion fully functioning, mutualistic primary role: transfer antigen information from mother neonate order calibrate its immune system, allowing survive microbial environment into which will emerge. Granted possesses function, logic suggests need robust, flexible, mechanism partition nutrition mature animal, thus ensuring continued existence vertebrate host guest, even under potentially unfavourable It feasible this process acts altering rate peristalsis following communication through gut–brain axis. The final step animal–microbiota symbiosis would then when key microbes transferred female her progeny, either live offspring eggs. According scheme, each animal inherits twice, once parents’ genetic material mother’s with aid father’s seminal microbiome, helps determine expression parental genes. point failure latter inheritance humans leads distinctive manifestations FGID including inflammation gut motility disturbances. Furthermore, seems likely critical microbiome–gut association occurs first few hours independent life, we term handshaking. Note if obvious disease childhood avoided, intrude later youth adulthood system disruption coexisting axis issues excessive weight gain poor health. principle, investigating perhaps supplementing maternal microbiota provide clinicians an unprecedented opportunity intervene long-term processes, before child born.